Michael Hooker Microscopy Facility (MHMF.ORG)

Publications which have used MHMF resources

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Last Updated: 08/21/2009 09:58:23 AM ~~(BEING ACTIVELY UPDATED)~~

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2009 Publications

Ostrowski LE, Yin W, Rogers TD, Busalacchi KB, Chua M, O'Neal WK, Grubb BR.
Conditional Deletion of Dnaic1 in a Murine Model of Primary Ciliary Dyskinesia Causes Chronic Rhinosinusitis.
Am J Respir Cell Mol Biol. 2009 Aug 12. [Epub ahead of print]

Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ.
CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.
PLoS Biol. 2009 Jul;7(7):e1000155. Epub 2009 Jul 21.

Kalantry S, Purushothaman S, Bowen RB, Starmer J, Magnuson T.
Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.
Nature. 2009 Jul 1. [Epub ahead of print]

Ribeiro CM, Hurd H, Wu Y, Martino ME, Jones L, Brighton B, Boucher RC, O'Neal WK.
Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia.
PLoS One. 2009 Jun 5;4(6):e5806

Cha JY, Maddileti S, Mitin N, Harden TK, Der CJ.
Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.
J Biol Chem. 2009 Mar 6;284(10):6227-40. Epub 2008 Dec 22.

Livraghi A, Grubb BR, Hudson EJ, Wilkinson KJ, Sheehan JK, Mall MA, O'Neal WK, Boucher RC, Randell SH.
Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment.
J Immunol. 2009 Apr 1;182(7):4357-67.

Martino ME, Olsen JC, Fulcher NB, Wolfgang MC, O'Neal WK, Ribeiro CM.
Airway Epithelial Inflammation-induced Endoplasmic Reticulum Ca2+ Store Expansion Is Mediated by X-box Binding Protein-1.
J Biol Chem. 2009 May 29;284(22):14904-13. Epub 2009 Mar 25.

About the Cover

Cover Figure On The Cover: Airway epithelial inflammation triggered by luminal exposure to Pseudomonas aeruginosa induces endoplasmic reticulum expansion, as visualized by calreticulin stain (green). Nuclei are stained with DAPI (4`,6-diamidino-2-phenylindole) (blue). The endoplasmic reticulum expansion results from activation of the unfolded protein response mediated by X-box binding protein-1. For details see the article by Martino et al., pages 14904–14913.

About the Cover

Cover Figure

Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Accumulation of recombinant adeno-associated virus (rAAV) particles in the nucleolus during infection. HeLa cells were infected with rAAV2 for 18 h and analyzed by immunofluorescence to detect intact capsids (yellow). A three-dimensional confocal reconstruction of infection is shown as separate frames to display progressive gating of the nucleus (blue, left) and reveal the interior of the nucleolus (magenta, subtracted from left to right). Two frames were enlarged (bottom of image) to highlight rAAV virions which enter the nucleus intact and accumulate in the nucleolus. (Johnson J., & Samulski, R. J.

Johnson J., & Samulski, R. J.
Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus.
J Virol. 2009 Mar;83(6):2632-44. Epub 2008 Dec 24

Cowley DO, Rivera-Pérez JA, Schliekelman M, He YJ, Oliver TG, Lu L, O'Quinn R, Salmon ED, Magnuson T, Van Dyke T 
Aurora-A kinase is essential for bipolar spindle formation and early development.
Mol Cell Biol. 2009 Feb;29(4):1059-71. Epub 2008 Dec 15.

Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED, Van Dyke T. 
Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.
Cancer Res. 2009 Jan 1;69(1):45-54.

Limberis MP, Vandenberghe LH, Zhang L, Pickles RJ, Wilson JM.
Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro. 
Mol Ther. 2009 Feb;17(2):294-301. Epub 2008 Dec 9.

Bukreyev A, Marzi A, Feldmann F, Zhang L, Yang L, Ward JM, Dorward DW, Pickles RJ, Murphy BR, Feldmann H, Collins PL. 
Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge.
Virology. 2009 Jan 20;383(2):348-61. Epub 2008 Nov 17.

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2008 Publications (Alphabetical order by first author's last name)

Bhati R, Patterson C, Livasy CA, Fan C, Ketelsen D, Hu Z, Reynolds E, Tanner C, Moore DT, Gabrielli F, Perou CM, Klauber-Demore N.
Molecular characterization of human breast tumor vascular cells.
Am J Pathol. 2008, 172, 1381-90.

Sun J, Hakobyan N, Valentino LA, Feldman BL, Samulski RJ, Monahan PE. Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.
Blood. 2008 Dec 1;112(12):4532-41. Epub 2008 Aug 20.

Berkowitz P, Chua M, Liu Z, Diaz LA, Rubenstein DS.
Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin.
Am J Pathol. 2008 Dec;173(6):1628-36

Donaldson EF, Yount B, Sims AC, Burkett S, Pickles RJ, Baric RS.
Systematic assembly of a full-length infectious clone of human coronavirus NL63.
J Virol. 2008 Dec;82(23):11948-57. Epub 2008 Sep 25.

Davis CW, Dickey BF
Regulated airway goblet cell mucin secretion.
Annu Rev Physiol. 2008;70:487-512. Review

Chamberlain SJ, Yee D, Magnuson T 
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency.
Stem Cells. 2008 Jun;26(6):1496-505.

Fulcher ML, Gabriel SE, Olsen JC, Tatreau JR, Gentzsch M, Livanos E, Saavedra MT, Salmon P, Randell SH 
Novel human bronchial epithelial cell lines for cystic fibrosis research.
Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L82-91. Epub 2008 Oct 31.

Hartnett ME, Martiniuk D, Byfield G, Geisen P, Zeng G, Bautch VL. 
Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease.
Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3107-14.

Kreda SM, Seminario-Vidal L, Heusden C, Lazarowski ER 
Thrombin-promoted release of UDP-glucose from human astrocytoma cells.
Br J Pharmacol. 2008 Apr;153(7):1528-37. Epub 2008 Jan 21.

Liu Y, Boukhelifa M, Tribble E, Morin-Kensicki E, Uetrecht A, Bear JE, Bankaitis VA.
The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals.
Mol Biol Cell. 2008 Jul;19(7):3080-96. Epub 2008 May 14.

Livraghi A, Mall M, Paradiso AM, Boucher RC, Ribeiro CM.
Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment.
Am J Respir Cell Mol Biol. 2008 Apr;38(4):423-34

Onesto C, Shutes A, Picard V, Schweighoffer F, Der CJ.
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
Methods Enzymol. 2008;439:111-29.

Papadeas ST, Halloran C, McCown TJ, Breese GR, Blake BL.
Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. 
J Comp Neurol. 2008 Nov 10;511(2):271-85.

Roberts PJ, Mitin N, Keller PJ, Chenette EJ, Madigan JP, Currin RO, Cox AD, Wilson O, Kirschmeier P, Der CJ.
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
J Biol Chem. 2008 Sep 12;283(37):25150-63. Epub 2008 Jul 9.

Saito Y, Uppal A, Byfield G, Budd S, Hartnett ME 
Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model.
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1591-8.

Sun J, Hakobyan N, Valentino LA, Feldman BL, Samulski RJ, Monahan 
PE.Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.
Blood. 2008 Dec 1;112(12):4532-41. Epub 2008 Aug 20.

Tatur S, Kreda S, Lazarowski E, Grygorczyk R.
Calcium-dependent release of adenosine and uridine nucleotides from A549 cells.
Purinergic Signal. 2008 Jun;4(2):139-146.

Zhang L, Theise N, Chua M, Reid LM.
The stem cell niche of human livers: symmetry between development and regeneration.
Hepatology. 2008 Nov;48(5):1598-607

Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF, Davis CW.
Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.
J Physiol. 2008 Apr 1;586(7):1977-92

Bartlett EJ, Hennessey M, Skiadopoulos MH, Schmidt AC, Collins PL, Murphy BR, Pickles RJ.
Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium. 
J Virol. 2008 Aug;82(16):8059-70. Epub 2008 Jun 4.

Johnson JS, Samulski RJ.
Enhancement of AAV infection by mobilizing capsids into and out of the nucleolus.
J Virol. 2008 Dec 24. [Epub ahead of print]

2007 Publications (Alphabetical order by first author's last name)

Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ.
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.J Biol Chem. 2007 Dec 7;282(49):35666-78

Livraghi A, Randell SH.
Cystic fibrosis and other respiratory diseases of impaired mucus clearance.
Toxicol Pathol. 2007;35(1):116-29. Review.

Grubb BR, Rogers TD, Kulaga HM, Burns KA, Wonsetler RL, Reed RR, Ostrowski LE.
Olfactory epithelia exhibit progressive functional and morphological defects in CF mice.
Am J Physiol Cell Physiol. 2007 Aug;293(2):C574-83.

Fanning AS, Little BP, Rahner C, Utepbergenov D, Walther Z, Anderson JM.
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties.
Mol Biol Cell. 2007 Mar;18(3):721-31.

Feng D, Marshburn D, Jen D, Weinberg RJ, Taylor RM 2nd, Burette A.
Stepping into the third dimension.
J Neurosci. 2007 Nov 21;27(47):12757-60. Review.

Burette A, Weinberg RJ
Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex.
J Comp Neurol. 2007 Feb 20;500(6):1127-35

Feng SM, Sartor CI, Hunter D, Zhou H, Yang X, Caskey LS, Dy R, Muraoka-Cook RS, Earp HS 3rd.
The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation.
Mol Endocrinol. 2007 Aug;21(8):1861-76.

Gentzsch, M., Choudhury, A. Chang, X.B., Pagano, R., Riordan, J.R.
Missambled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking.
J. Cell Sci. 2007;120:447-455.

Hickey AJ, Mansour HM, Telko MJ, Xu Z, Smyth HD, Mulder T, McLean R, Langridge J, Papadopoulos D.
Physical Characterization of Component Particles included in Dry Powder Inhalers: I. Strategy Review and Static Characteristics. (Invited Paper)
J Pharm Sci: Special Issue David Grant Dedicated Issue 2007 Jan;96: (ACCEPTED, IN PRESS)

Karrasch T, Kim JS, Muhlbauer M, Magness ST, Jobin C.
Gnotobiotic IL-10^-/-;NF-κB^EGFP Mice Reveal the Critical Role of TLR/NF-κB Signaling in Commensal Bacteria-Induced Colitis.
J Immunol. 2007 May 15;178(10):6522-32.

Kreda SM, Okada SF, van Heusden CA, O'neal W, Gabriel S, Abdullah L, Davis CW, Boucher RC, Lazarowski ER.
Coordinated Release of Nucleotides and Mucin from Human Airway Epithelial Calu-3 Cells.
J Physiol. 2007 Oct 1;584(Pt 1):245-59. Epub 2007 Jul 26.

Maile LA, Capps BE, Ling Y, Xi G, Clemmons DR.
Hyperglycemia alters the responsiveness of smooth muscle cells to Insulin-Like Growth Factor-I.
Endocrinology 2007 May;148(5):2435-43.

Mitin N, Betts L, Yohe ME, Der CJ, Sondek J, Rossman KL.
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat Struct Mol Biol. 2007 Aug 19; [Epub ahead of print]

Rossi AH, Salmon WC, Chua M, Davis CW.
Calcium signaling in human airway goblet cells following purinergic activation.
Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L92-8. Epub 2006 Sep 1.

Tatur, S; Kreda, SM; Lazarowski, E and Grygorczyk, R
Calcium-dependent release of adenosine and uridine nucleotides from A549 cells
PUSI 2006;(in press)

Thelin WR, Chen Y, Gentzsch M, Kreda SM, Sallee JL, Scarlett CO, Borchers CH, Jacobson K, Stutts MJ, Milgram SL.
Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR.
J Clin Invest. 2007 Feb 1;117(2):364-374.

Wightman RM, Heien ML, Wassum KM, Sombers LA, Aragona BJ, Khan AS, Ariansen JL, Cheer JF, Phillips PE, Carelli RM.

Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens.

Eur J Neurosci. 2007 Oct;26(7):2046-54. Epub 2007 Sep 14.

Zucker RM, Rigby P, Clements I, Salmon W, Chua M.
Reliability of confocal microscopy spectral imaging systems: Use of multispectral beads.
Cytometry A. 2007 Mar;71(3):174-89.

2006 Publications (Alphabetical order by first author's last name)

Berkowitz P, Hu P, Warren S, Liu Z, Diaz LA, Rubenstein DS.
p38MAPK inhibition prevents disease in pemphigus vulgaris mice.
Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12855-60.

Chalermskulrat W, McKinnon KP, Brickey WJ, Neuringer IP, Park RC, Sterka DG, Long BR, McNeillie P, Noelle RJ, Ting JP, Aris RM.
Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance.
Thorax. 2006 Jan;61(1):61-7.

Dejima K, Randell SH, Stutts MJ, Senior BA, Boucher RC.
Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis.
Arch Otolaryngol Head Neck Surg. 2006 Dec;132(12):1352-62.

Ding JD, Weinberg RJ. 
Localization of soluble guanylyl cyclase in the superficial dorsal horn. 
J Comp Neurol. 2006 Apr 20;495(6):668-78.

Donaldson SH, Bennett W, Zeman K, Knowles MR, Tarran R, and Boucher RC.
Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline.
NEJM 2006; 354(3):241-250.

Donaldson SH, et al.
Studies look to sea for cystic fibrosis treatment: Inhaled saline solution works where drugs failed, doctors say
By Peggy Peck, MedPageToday Managing Editor
Thursday, January 19, 2006, http://www.cnn.com/2006/HEALTH/conditions/01/18/cf.saltwater/

Everett RS, Vanhook MK, Barozzi N, Toth I, Johnson LG.
Specific Modulation of Airway Epithelial Tight Junctions by Apical Application of an Occludin Peptide.
Mol Pharmacol. 2006 Feb;69(2):492-500.

Fanning AS, Little BP, Rahner C, Utepbergenov D, Walther Z, Anderson JM.
The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction Strand Localization and Scaffolding Properties.
Mol Biol Cell. 2006 Dec 20; [Epub ahead of print]

Geisen P, McColm JR, Hartnett ME.
Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor.
Exp Eye Res. 2006 Apr;82(4):608-19.

Grubb BR, Rogers TD, Diggs PC, Boucher RC, Ostrowski LE.
Culture of murine nasal epithelia: model for cystic fibrosis.
Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L270-7.

Hartnett ME, Martiniuk DJ, Saito Y, Geisen P, Peterson LJ, McColm JR.
Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy.
Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4975-82.

Hodson CA, Ambrogi IG, Scott RO, Mohler PJ, Milgram SL.
Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal.
Traffic. 2006 Apr;7(4):456-64.

Hu P, Berkowitz P, Madden VJ, Rubenstein DS.
Stabilization of plakoglobin and enhanced keratinocyte cell-cell adhesion by intracellular O-glycosylation.
J Biol Chem. 2006 May 5;281(18):12786-91.

Jubin Ryu, Lidong Liu, Tak Pan Wong, Dong Chuan Wu, Alain Burette, Richard Weinberg, Yu Tian Wang, Morgan Sheng
A Critical Role for Myosin IIB in Dendritic Spine Morphology and Synaptic Function.
Neuron 2006;49(2):175-182.

Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T.
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
Nat Cell Biol. 2006 Feb;8(2):195-202.

Kalantry S, Magnuson T.
The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation.
PLoS Genet. 2006 May;2(5):e66. Epub 2006 May 5.

Kim S, Burette A, Chung HS, Kwon SK, Woo J, Lee HW, Kim K, Kim H, Weinberg RJ, Kim E
NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation
Nature Neuroscience, 2006 Oct;9(10):1294-301.

McCaskill JG, Chason KD, Neuringer IP, Ghio AJ, Funkhouser WK, Tilley SL.
Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice.
Am J Respir Cell Mol Biol. 2006 Sep;35(3):347-56.

McColm JR, Geisen P, Peterson LJ, Hartnett ME.
Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis.
Exp Eye Res. 2006 Aug;83(2):438-46.

McKay T, Patel M, Pickles RJ, Johnson LG, Olsen JC.
Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors.
Gene Ther. 2006 Apr;13(8):715-24.

Mousley CJ, Tyeryar KR, Ryan MM, Bankaitis VA.
Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast.
Biochem Soc Trans. 2006 Jun;34(Pt 3):346-50. Review.

Okada SF, Nicholas RA, Kreda SM, Lazarowski ER, Boucher RC.
Physiological regulation of ATP release at the apical surface of human airway epithelia.
J Biol Chem. 2006 Aug 11;281(32):22992-3002. Epub 2006 Jun 5.

Perez-Vilar J, Mabolo R, McVaugh CT, Bertozzi CR, Boucher RC.
Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion.
J Biol Chem. 2006 Feb 24;281(8):4844-55.

Phillips SE, Ile KE, Boukhelifa M, Huijbregts RP, Bankaitis VA.
Specific and Nonspecific Membrane-binding Determinants Cooperate in Targeting Phosphatidylinositol Transfer Protein beta-Isoform to the Mammalian Trans-Golgi Network.2
Mol Biol Cell. 2006 Jun;17(6):2498-512.

Purfield AM., Barrett MP, Tidwell RR, Meshnick, SR.
DB75, a novel diamidine, targets the /Plasmodium falciparum/ nucleus.
Abstract at the annual meeting of the American Society for Tropical Medicine and Hygiene, Atlanta, GA, 2006

Qi J, Chi L, Maloney M, Yang X, Bynum D, Banes AJ.
Interleukin-1beta Increases Elasticity of Human Bioartificial Tendons.
Tissue Eng. 2006 Oct;12(10):2913-25.

Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ.
IL-1beta decreases the elastic modulus of human tenocytes.
J Appl Physiol. 2006 Jul;101(1):189-95. Epub 2006 Apr 20.

Randell SH.
Airway Epithelial Stem Cells and the Pathophysiology of Chronic Obstructive Pulmonary Disease.
Proc Am Thoracic Soc. 2006; 3:1-8

Ribeiro CM.
The role of intracellular calcium signals in inflammatory responses of polarised cystic fibrosis human airway epithelia.
Drugs R D. 2006;7(1):17-31. Review.

Jaime A. Rivera-Pérez, Hunter Diefes, Terry Magnuson
A simple enzymatic method for parietal yolk sac removal in early postimplantation mouse embryos.
Developmental Dynamics, 2006, 236, 489-493

Tarran R, Trout L, Donaldson SH, Boucher RC.
Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia.
J Gen Physiol. 2006 May;127(5):591-604.

Utepbergenov DI, Fanning AS, Anderson JM.
Dimerization of the scaffolding protein ZO-1 through the second PDZ domain.
J Biol Chem. 2006 Aug 25;281(34):24671-7.

Zeng G, Taylor SM, McColm JR, Kappas NC, Kearney JB, Williams LH, Hartnett ME, Bautch VL.
The orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation.
Blood. 2006 Oct 26; [Epub ahead of print]

2005 Publications (Alphabetical order by first author's last name)

Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS.
Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization.
J Biol Chem. 2005 Jun 24;280(25):23778-84.

van Buul JD, Anthony EC, Fernandez-Borja M, Burridge K, Hordijk PL.
Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation.
J Biol Chem. 2005 Jun 3;280(22):21129-36.

Chandrasekharan S, Foley NA, Jania L, Clark P, Audoly LP, Koller BH.
Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.
J Lipid Res. 2005 Dec;46(12):2636-48.

Chenette EJ, Abo A, Der CJ.
Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase.
J Biol Chem. 2005 Apr 8;280(14):13784-92.

Choi J, Ko J, Racz B, Burette A, Lee JR, Kim S, Na M, Lee HW, Kim K, Weinberg RJ, Kim E 
Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases. 
J Neurosci 2005;26:869-79.

Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC 2nd.
Rap1b is required for normal platelet function and hemostasis in mice.
J Clin Invest. 2005 Mar;115(3):680-7. Erratum in: J Clin Invest. 2005 Aug;115(8):2296.

Das S, Palmer OP, Leight WD, Surowitz JB, Pickles RJ, Randell SH, Buchman CA.
Cytokine amplification by respiratory syncytial virus infection in human nasal epithelial cells.
Laryngoscope. 2005 May;115(5):764-8.

Ding JD, Burette A, Weinberg RJ 
Expression of soluble guanylyl cyclase in rat cerebral cortex during postnatal development. 
J Comp Neurol 2005;485(3):255-265.

Ehre C, Rossi AH, Abdullah LH, De Pestel K, Hill S, Olsen JC, Davis CW.
Barrier role of actin filaments in regulated mucin secretion from airway goblet cells.
Am J Physiol Cell Physiol. 2005 Jan;288(1):C46-56. Epub 2004 Sep 1.

Flierl A, Chen Y, Coskun PE, Samulski RJ, Wallace DC.
Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse.
Gene Ther. 2005 Apr;12(7):570-8.

Grieger JC, Samulski RJ.
Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps.
J Virol. 2005 Aug;79(15):9933-44.

Hill R, Song Y, Cardiff RD, Van Dyke T.
Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.
Cell. 2005 Dec 16;123(6):1001-11.

Johnson LG.
Applications of imaging techniques to studies of epithelial tight junctions.
Adv Drug Deliv Rev. 2005 Jan 2;57(1):111-21.

Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC.
Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia.
Mol Biol Cell. 2005 May;16(5):2154-67.

Li, Y.^†, Fanning, A.S.^†, Anderson, J.M. and A. Lavie 
Structure and Mutagenesis of the Occludin Distal C-terminal Cytoplasmic Domain Implicates a Basic Region as the ZO-1 Binding Surface.
J Mol Biol. 2005 Sep 9;352(1):151-64.

Madamanchi NR, Moon SK, Hakim ZS, Clark S, Mehrizi A, Patterson C, Runge MS.
Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms.
Arterioscler Thromb Vasc Biol. 2005 May;25(5):950-6. Epub 2005 Mar 3.

Matsui H, Verghese MW, Kesimer M, Schwab UE, Randell SH, Sheehan JK, Grubb BR, Boucher RC.
Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces.
J Immunol. 2005 Jul 15;175(2):1090-9.

Melone M, Burette A, Weinberg RJ 
Light microscopic identification and immunocytochemical characterization of glutamatergic synapses in brain
sections. 
J Comp Neurol 2005;492 (4):495-509

Neuringer IP, Chalermskulrat W, Aris R.
Obliterative bronchiolitis or chronic lung allograft rejection: a basic science review.
J Heart Lung Transplant. 2005 Jan;24(1):3-19.

Neuringer IP, Sloan J, Budd S, Chalermskulrat W, Park RC, Stonebraker JR, O'Neal WK, Aris RM, Randell SH.
Calcineurin inhibitor effects on growth and phenotype of human airway epithelial cells in vitro.
Am J Transplant. 2005 Nov;5(11):2660-70.

Perez-Vilar J, Ribeiro CM, Salmon WC, Mabolo R, Boucher RC.
Mucin granules are in close contact with tubular elements of the endoplasmic reticulum.
J Histochem Cytochem. 2005 Oct;53(10):1305-9

Ribeiro CM, Paradiso AM, Carew MA, Shears SB, Boucher RC.
Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia.
J Biol Chem. 2005 Mar 18;280(11):10202-9.

Perez-Vilar J, Olsen JC, Chua M, Boucher RC.
pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells.
J Biol Chem. 2005 Apr 29;280(17):16868-81.

Ribeiro CM, Paradiso AM, Schwab U, Perez-Vilar J, Jones L, O'neal W, Boucher RC.
Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia.
J Biol Chem. 2005 May 6;280(18):17798-806

Routt SM, Ryan MM, Tyeryar K, Rizzieri KE, Mousley C, Roumanie O, Brennwald PJ, Bankaitis VA.
Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast.
Traffic. 2005 Dec;6(12):1157-72.

Sims AC, Baric RS, Yount B, Burkett SE, Collins PL, Pickles RJ.
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs.
J Virol. 2005 Dec;79(24):15511-24.

Stonebraker JR, Wagner D, Lefensty RW, Burns K, Gendler SJ, Bergelson JM, Boucher RC, O'Neal WK, Pickles RJ.
Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection.
J Virol. 2004 Dec;78(24):13755-68.

Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC.
Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.
J Biol Chem. 2005 Oct 21;280(42):35751-9.

Thelin WR, Kesimer M, Tarran R, Kreda SM, Grubb BR, Sheehan JK, Stutts MJ, Milgram SL.
The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.
J Biol Chem. 2005 Dec 16;280(50):41512-20. Epub 2005 Oct 20.

Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME
The Rac1-GEF Tiam1 Couples the NMDA Receptor to the Activity-Dependent Development of Dendritic Arbors and Spines. 
Neuron 2005;45:525-538.

Vincent P, Chua M, Nogue F, Fairbrother A, Mekeel H, Xu Y, Allen N, Bibikova TN, Gilroy S, Bankaitis VA.
A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes membrane growth of Arabidopsis thaliana root hairs.
J Cell Biol. 2005 Feb 28;168(5):801-12.

Xu D, McCarty D, Fernandes A, Fisher M, Samulski RJ, Juliano RL.
Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector.
Mol Ther. 2005 Apr;11(4):523-30.

Zhang L, Bukreyev A, Thompson CI, Watson B, Peeples ME, Collins PL, Pickles RJ.
Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium.
J Virol. 2005 Jan;79(2):1113-24.

Zucker RM, Lerner JM.
Wavelength and alignment tests for confocal spectral imaging systems.
Microsc Res Tech. 2005 Dec 1;68(5):307-19.

2004 Publications (note this section is currently incomplete)

Ellerbroek SM, Wennerberg K, Arthur WT, Dunty JM, Bowman DR, DeMali KA, Der C, Burridge K.
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.
Mol Biol Cell. 2004 Jul;15(7):3309-19.

Hirsh AJ, Sabater JR, Zamurs A, Smith RT, Paradiso AM, Hopkins S, Abraham WM, Boucher RC.
Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease.
J Pharmacol Exp Ther. 2004 Dec;311(3):929-38.

Kreda, SM; Mall, M; Mengos, A; Jensen, TJ; Hirtz, S; Seydewitz, HH; Yankaskas, J; Kunzelmann, K; Riordan, JR and Boucher, RC
The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon
Gastroenterology 2004;126:32-41

Lazarowski E. R., Tarran R., Grubb B. R., van Heusden C., and Boucher
R. C. Nucleotide release provides a mechanism for airway surface liquid homeostasis.
J. Biol. Chem. 2004;279:35551-35556

Lerner JM, Zucker RM.
Calibration and validation of confocal spectral imaging systems.
Cytometry A. 2004 Nov;62(1):8-34. Review.

Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC.
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.
Nat Med. 2004 May;10(5):487-93.

McColm JR, Geisen P, Hartnett ME.
VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: Relevance to clinical ROP.
Mol Vis 2004;10: 512-20

Perez-Vilar J, Randell SH, Boucher RC.
C-Mannosylation of MUC5AC and MUC5B Cys subdomains.
Glycobiology. 2004 Apr;14(4):325-37.

2003 Publications (note this section is currently incomplete)

Ribeiro, C. M. P., Paradiso, A. M., Livraghi, A., and Boucher, R. C. (2003): The mitochondrial barriers segregate agonist-induced calcium-dependent functions in human airway epithelia. J. Gen. Physiol. 122: 377-387.

Schwab, U. E., Ribeiro, C. M. P., and Boucher, R. C. (2003): Role of the Actin Filament Network in Burkholderia multivorans Invasion in Well-Differentiated Human Airway Epithelia. Infect. Immun. 71: 6607-6609.

Coyne, C. B., Ribeiro, C. M. P., Boucher, R. C., and Johnson, L. G. (2003): Acute mechanism of medium chain fatty acid-induced enhancement of airway epithelial permeability. J. Pharm. Experim. Therap. 305: 440-450.

Van Itallie, C.M., Fanning A.S., and Anderson, J.M. (2003) Reversal of Charge Selectivity in Anion or Cation permeable Cell Lines by Expression of Different Claudins. Am. J. Physiol. Renal Physiol 285(6):F1078-84.

Jaime A. Rivera-Pérez, Jesse Mager and Terry Magnuson, (2003) Dynamic morphogenetic events characterize the mouse visceral endoderm, Developmental Biology 261(2), 470-487.

2002 Publications (note this section is currently incomplete)

Fanning A.S.*, Ma, T.Y., and Anderson, J.M. (2002) Isolation and Functional Characterization of the Actin-Binding Region in the Tight Junction Protein ZO-1.
FASEB J. 10.1096/fj.02-0121fje.

Schwab, U., Leigh, M., Ribeiro, C., Yankaskas, J., Burns, K., Gilligan, P., Sokol, P., and Boucher, R. (2002):
Patterns of epithelial invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelial cells. Infect.
Immun. 70:4547-4555.


		Copyright 2001-09 Dr. M. Chua, Office of Research, School of Medicine, University of North Carolina, Chapel Hill, NC 27599
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Last Updated: 2009-08-21